Hypertension due to ischemia of one kidney. A survey of twenty years' experience.

An invitation to speak at Yale University in commemoration of John Punnett Peters is a great honor and is accepted as a rare privilege. To a whole generation of Yale medical students and also to the medical profession at large, Dr. Peters epitomized the best of the scientific approach toward understanding and correction of disease, which is, after all, the procedure through which medical knowledge accomplishes its most significant advances. No man made more contributions toward the interpretation of normal and disease processes by the use of chemical methods than did Dr. Peters. It was not my good fortune to study directly under him. But because our paths of endeavor lay along similar lines and because of joint membership in a small medical club in which there has always been close intimacy and friendship, I came to see quite a bit of this extraordinary man. Under a canopy of jocular gruffness, there lay the gentlest of hearts; and I doubt that Jack Peters would knowingly have hurt a flea, except in an effort to confound evil. No one was ever more loyal to his friends. He was, however, the most exacting man of my acquaintance; and perfection was demanded of himself as well as of others. Jack delighted in argument and the give and take of violent debate. The only times I ever got the better of him in conflict was on the tennis court; but this was unfair since it resembled somewhat Br'er Rabbit's advantage over Br'er Fox in the brier patch. In accepting the invitation to stand before you, under Dr. Peters' aegis as it were, it has not been easy to choose a subject for discussion that is within my capabilities and, at the same time, would be "in the Peters mood." He would have liked controversy and something in the way of new theory or approach which would excite disagreement and debate. I have chosen, therefore, to discuss with you some reflections on hypertension as related to renal ischemia, and to offer some deductions derived from an interest in this subject over a 20-year span. Within this subject